Pinky e Cérebro são dois ratos brancos de laboratório. Pinky é o alto e magricela, infantil e abobalhado que sempre irrita e atrapalha Cérebro. Este, o baixinho mau-humorado, semore tem planos mirabolantes para conquistar o seu maior objetivo: conquistar o mundo.
Rob Paulsen • Maurice LaMarche
Cérebro faz um plano para hipnotizar as pessoas, mas ele precisa de carne de caranguejo branca para ter sucesso. A fim de obter a carne de caranguejo, ele leva um submarino para o naufrágio do Titanic. Infelizmente, a CIA identifica seu submarino e ordena sua destruição.
Brain plans to take over the world by creating a voice mail system that will tie up everyone on the planet long enough for him to take over. In order to do this he needs money. He decides to get it by getting a job and then staging an accident in order to sue the company.
Brain uses an enlarging ray to make himself and Pinky four hundred feet tall. With Pinky dressed as a Gollyzilla, Brain stages a fight to make himself look like hero. But then the real Gollyzilla shows up.
Brain makes Pinky smarter so his stupidity won't ruin anymore plans.
Pinky and Brain perform a song about the brain.
Brain gains the ability to cloud the minds of men with his voice. He tries to get on the radio by adapting the persona of "The Fog". Unfortunately his plan falls apart when he gets to the studio.
Brain tries to get all the people off Earth onto his paper mache creation, Chia Earth.
Using Johannes Gutenberg printing press, the Brain make a series of collectible trading cards.
A successful modern artist is born and it's Pinky, trying to help fund Brain's new plan.
Brain hopes his inter-galactic pen pal, Zalgar, will help him take over the world. But it turns out Zalgar likes to snack on brains.
Pinky writes a letter to the newspaper criticizing the comic strip "The Family Circus". His letter, however, is misunderstood as a political statement that thrusts him to a spotlight that leads him to the Presidency of the United States. Pinky's administration, however, must deal with a scandal when the Brain's plans to take over the world are made public.
Brain makes a tearjerker movie to make the world sad enough to make him leader.
Animal rights activist think Pinky and the Brain are monkeys and release them into the jungle after taking them out of Acme Labs. The pair try to make it back home, but run into the Brain's old enemy Snowball.
Brain tries to discover what makes the legendary Samson so strong.
When Brain comes to the conclusion he no longer wants to take over the world, he decides to help others who had his problem and the first one to be helped is Pinky.
Pinky and Brain get sealed in an Egyptian pyramid where a mummy is lurking about.
Brain gets a group of men to steal money from the rich (ala Robin Hood) to pay for his new plot.
Pinky and Brain stumble upon a super powered baby, who happened to arrive from an exploding alien world.
Pinky and Brain have to brave a virtual reality maze to find a microchip crucial to Brain's new plot.
The mice's future selves arrive in the lab, sending them on a roller coaster ride through time to find a world domination kit.
Pinky and Brain's DNA get merged during a cloning experiment, creating a new mouse.
Brain enlists the aid of beavers to gain control over the flow of rivers.
The mice make a series of comedy films and hit the big time.
Pinky and Brain have a new companion, Larry, but their newest plan just doesn't seem to pan out.
In their latest plan, Pinky and Brain try to take over the steel mills in Pittsburgh, Pennsylvania by pretending to be a part of an endangered species called the Mousealopes.
It's 1946 and Brain's new plan gets interrupted when he and Pinky encounter Billie and Snowball.
Brain gets caught up in winning a golf tournament, even though it interferes with his new plan.
After the Earth gets the power of speech from his Silitronlinguifactor device, Brain comes up with a new plan.
Brain tries to get a package meant for him back from his neighbor.
Pinky becomes a guru during the 1960s.
It's Brain's birthday and Pinky plans a surprise party.
After getting a glimpse of his future, Brain abandons his attempts to take over the world and gets a job as a ski instructor.
The mice are looking to control tornados, but a pest keeps getting in their way.
Brain sings about past and present world leaders' failures.
The mice need to get into a mine, but have to pretend to join a Amish-type society.
Brain's latest plan is a conspiracy theory about why he is not ruling the world.
Brain becomes a tap dancer with steam-powered legs in order to spread a subliminal morse code at the World's Fair.
Pinky and Brain are kidnapped in Washington, DC by an unknown force. Brain loses his memory and the mice are then imprisoned in a town where everyone is forced to perform the Schëerskåhøvên, which is dumbing down the entire country.
Brain regains his memory and the mice escape. They believe Snowball is responsible for the Schmëerskåhøvên, but him imprisoned in a mental institution.
The mice and Snowball search for the one who spliced their DNA, Dr. Mordough, thinking he's responsible for all this. But it turns out to be his cat, Precious, and time is running out.
Pinky and Brain's plan to alter caviar with a mutating capsule is complicated by a Russian lab mouse.
Brain plots to make every clock on Earth chime repeatedly.
A special of highlights of their career is on the air, but it's really all a ruse so Pinky and Brain can hypnotize the viewers.
Inspired by legends of the past, Brain tries to create a legend about himself to gain world acclaim.
How Acme Labs became home to Pinky and Brain.
In the series finale of Pinky and the Brain, the Brain, and the characters from Animaniacs develop a Star Wars spoof.