Ruby Walker é uma jovem médica que procura começar um novo capítulo de sua vida após o fim de seu relacionamento. A residente do Reino Unido muda-se uma comunidade na Índia, onde faz o possível para se misturar.
A junior doctor becomes disillusioned with her life and decides to leave the UK. She heads for South India hoping to make a fresh start, and finds a new home working in an under-resourced and over-worked cottage hospital run by an eccentric English ex-pat.
The team race against the clock to treat a local snake catcher.
As Holi festival fever hits The Good Karma Hospital, an abandoned baby strikes a personal chord with Ruby. Meanwhile, Lydia is reacquainted with an aging ex-pat artist, whose alternative life choices may be about to catch up with him.
On the day that he is attending a lavish Indian wedding, Ram clashes with Lydia when a medical case gets personal. Meanwhile, as Ruby treats a patient from the UK whose story doesn't quite add up, she's left questioning where she truly belongs.
Lydia and Ruby visit a convent to make a seemingly miraculous diagnosis, but Lydia's interference in the destiny of a young nun backfires bringing Lydia and Ruby to blows. Meanwhile, Maggie and Paul join local pilgrims trekking through the jungle - is Maggie searching for her own miracle?
As the first monsoon rains arrive, tensions run high between Lydia and Ruby leading Ruby to make a shock decision. Meanwhile, Maggie's health is rapidly declining, and with her daughter insisting on returning to the UK, will Maggie be granted her dying wish to stay in India?