A série apresenta a Mistério S/A após terminar seu último ano do ensino médio. Fazendo planos para gastar a sua última parada de verão como uma equipe, eles decidem viajar na Máquina do Mistério para buscar o prazer e aventura. Ao longo do caminho, no entanto, se deparam com uma enorme quantidade de monstros e estragos, impedindo-os de terminar sua jornada.
Matthew Lillard • Grey DeLisle • Kate Micucci • Frank Welker
Velma's got an interview at the prestigious Kingston University, the most selective school in the country. The only catch? The dean wants her and the rest of the Scooby gang to figure out why the ghost of Elias Kingston, the school's founder, is haunting Kingston's book-filled halls!
Fred gets a call for help from Chuck, his daredevil of a best friend, leading the gang on a rescue mission deep into caverns of an ancient civilization that worships chickens.
The gang climbs aboard the cruise ship run by Fred's cousin despite Velma's strong dislike of water.
The gang visits the set of Scooby's favorite TV show and he meets a dog actress who plays a detective on the show.
Shaggy takes the gang to the Minor League Baseball stadium of his youth only to learn it's about to be shut down because a ghostly baseball player is scaring away all the fans.
Fred and the Gang go to the history of mysteries museum. When the God Sobek trashes the Egypt Exhibit the tour guide offer challenges Fred's leadership and leads the Gang.
To solve the mystery of a creepy Crystal Crawler - a bat-like cave monster - the Gang must venture into the Crystal Canopy - a labyrinth of intricate crystal formations. To make things worse, they can't speak a word while in the Canopy, because even the slightest sound will bring the crystals crashing down around them!
The gang is invited to a monster mystery party, where they try solve the mystery of a fake ghostly apparition. When a real monster shows up though, Daphne Blake and Fred Jones are left to solve the mystery on their own, because no one else will believe them.
To solve the mystery of a ghostly performer haunting her former venue, the Gang has to pretend to be a rock band themselves! But can they solve the case before Velma has to actually get on stage and sing?
Shaggy and Scooby's favorite chef is finally opening his own restaurant but a monstrous Yeti threatens the opening night. The gang has to solve the mystery before dessert is served, while Shaggy and Scooby have to resist eating all the food that's meant for the customers!
The gang visits a technology company to solve the mystery of an evil robot who has been wreaking havoc.
Daphne had always dreamed of meeting extraterrestrial life, but that dream becomes a nightmare when the gang gets caught up in the mystery of a scary alien monster and brought to Area 53 - a government facility so secret, it's two numbers higher than Area 51!
It's a classic haunted house caper when a rich man, whose life Scooby once saved, writes Scooby into his will! Now, to collect his share of the fortune the gang must spend a night in a creepy mansion along with the rich man's kooky relatives and a spooky phantom!
The gang visits the town of Rockwellville in search of a Christmas mystery, but all they find is a pterodactyl who seems to have nothing to do with Christmas. Meanwhile, Daphne, who is tired of having her December 25th birthday overshadowed year after year, tries to convince the gang to celebrate her birthday instead of Christmas.
Fred takes the gang to visit The Vault, an old prison that is haunted by the ghost of Stealin' Stan, who died trying to escape from the prison.
The gang goes aboard the Air Gigantica and tries to stop a gremlin from sabotaging the flight. Meanwhile, after the pilot quits, Daphne has to try to land the plane safely before it crashes.
The gang goes to the Sorcerer Snacks factory, where a real sorcerer is scaring everyone away. Meanwhile, Fred finds he can get Shaggy and Scooby to do anything he wants with a box of Sorcerer Snacks (a precursor to Scooby Snacks).
The gang visits a bayou in New Orleans, where a swamp monster is frightening away anyone who comes into his swamp. Meanwhile, Daphne pretends to be a vampire.
The gang's trip to a ski resort is interrupted by a snow monster terrorizing the tourists. Meanwhile, Daphne attempts to get revenge on Fred for hitting her with a snowball three years ago by planning a snowball attack.
Daphne takes the gang to her family's ancient castle where a giant is protecting it from the visitors. As the gang tries to solve the mystery, Daphne starts speaking Irish and Fred wears knight armor.
The gang goes to a farm, where Fred develops a crush on Beth, a farmer's daughter. When a living scarecrow appears, Fred tries to impress Beth with his mystery solving skills, while Velma gets severe hay allergies and Daphne begins hoarding animals as "pets" after becoming jealous of Shaggy and Scooby's relationship.
After the ghost of the Cliff Bride begins haunting a wedding that the gang is attending, they must go to extreme lengths to try to keep the bride, who is very superstitious, from finding out. However, this proves very challenging when the ghost seems to appear everywhere that the bride is. Meanwhile, Daphne becomes very wrapped up in the ideology of wedding traditions and Shaggy worries obsessively about his best man speech.
Fred takes the gang to Mexico so they can experience the local Day of the Dead festivities. A mystery quickly pops up involving a long-dead historical figure named El Bandito, causing Fred to want to make himself a legend just like El Bandito. During the mystery, Daphne believes her deceased Aunt Cookie is communicating with her somehow.
After Daphne agrees to babysit her friend's son, Wayne, the gang ends up going to an amusement park where an insane killer clown is lurking. Daphne attempts to focus on allowing Wayne to have a good time, but the rest of the gang investigates the park and tries to solve the mystery of Madcap, the killer clown.
Fred attempts to hone the gang's mystery solving skills by taking them out camping in the wilderness. A perfect mystery opportunity soon comes along when they discover that viking ghosts have scared away all the tourists from camping in the area. However, the gang has to avoid the park ranger in the process, or risk being sent to "Forest Jail" forever.
Fred is put on trial after he is wrongfully accused of dressing up as a toxic waste mutant. The trial goes further awry after Fred is accused of inventing every mystery he has ever solved. Though Daphne agrees on being Fred's defense lawyer, her and the rest of the gang's antics serve no help to Fred, who risks being put away in prison if charged with the crime.
While trick-or-treating with his cousin Scott and a friend when he was little, Fred has a scarring experience when he is ambushed by an evil witch near an abandoned cabin. Several years later, Fred and the gang run into the very same witch on Halloween night in another town. As the gang attempts to solve the mystery of the witch, they must also convince Fred that he is incorrect in his belief that a mystery cannot be solved on Halloween night.
The gang travels to Britain in 1843-ish and runs into Scrooge who claims he was attacked by the ghost of his partner Jacob Marley and that three more ghosts are coming. The gang agrees to solve the mystery but Velma wonders if she has more potential than just solving mysteries.
With Fred not sleeping the gang decides it is time for a vacation. However their relaxation is short lived when a monster shark terrorizes the beach. The gang must solve the mystery whilst making sure Fred relaxes and doesn't get involved
When Scooby falls sick, the gang immediately rushes him to the hospital, only to discover it is being haunted by a werewolf. The gang must help Scooby and solve the mystery.
The gang heads to a renaissance fair from Velma's childhood and must act out the middle ages. A mystery is revealed when the spirit of a jester begins attacking the fair and the gang must quickly come to the rescue.
Shaggy and Scooby, sick of the monsters and mysteries, leave the Mystery Gang.
The gang decides to go to a dog show in New York, but they soon discover a mystery. With Fred undercover, Scooby trying to win the respect of other dogs, and Velma and Shaggy switching personalities, it's going to be a tough case to crack.
The gang is on a 3-day trip on a train, but when 8 monsters from different parts of the world appear, it's time for action. The monsters are the Grim Reaper, a Mummy, Tzitzimitl, Haniver, a Manticore, Hemogoblin, Tengu, and Tarasque.
Fred tries to solve a 700-year-old mystery in Japan; Daphne becomes a viral sensation.
Velma runs for mayor to bait the ghost that has returned to a town and scare the mayoral candidates.
A virus infects an asteroid mining crew one by one, turning them into evil skull-headed aliens.
To escape a snowstorm, the gang checks into a creepy hotel run by a man with strict rules.
The gang tours an old Hollywood Studio, but they soon uncover a mystery concerning the ghost of a silent film comedy star who has returned to make sure his recently discovered final film is never seen.
Fred gets to live out his childhood dream of being a stage magician when a mutant rabbit monster terrorizes a magic club.
The gang gets trapped in an ancient Greek palace, where they must find a scroll to escape.
Shaggy is surprised to see his old childhood first crush has become a goth; embarrassed that he hasn't changed at all, Shaggy attends a goth party with the gang.
The gang gets caught up in international espionage when they cross paths with British secret agent, Jenny Vex, and must help her complete her dangerous mission.
Fred's worst nightmare comes true when an evil spirit possesses the Mystery Machine and turns his beloved van into an unrelenting monster.
Daphne brings the gang to a fancy ice hotel where a new exhibit of ice age artifacts is opening; things heat up when a frozen Ice Man goes on a rampage inside the hotel.
The gang heads to Shaggy's beloved grandmother's Florida retirement home, where they learn a crazed ape man has been frightening the elderly residents.
Scooby Doo runs into an old kennel mate from the rescue shelter, Axel, who is now a state-of-the-art, highly trained K-9 police dog.
When a successful video game company tries to convince Velma to work for them in San Francisco, the gang becomes embroiled in the mystery of a video game villain.
The gang are caught in a witch's revenge for the Salem witch trials.
The gang investigate the mysterious Professor Huh?, who pits them against another rival gang led by a childhood friend of Fred.
The gang investigate the mysterious Professor Huh?, who pits them against another rival gang led by an old childhood friend of Fred.
Shaggy drags the gang to an arcade where the animatronic mascot has apparently come to life.