Criada por MacFarlane e Mark Hentemann, a série é situada na cidade ficcional de Bordertown, próxima à fronteira com o México. Bud Buckwald é um agente que tem como função patrulhar a fronteira. Casado e pai de três filhos, Bud tenta lidar com as mudanças culturais que a cidade vem sofrendo nos últimos anos. Seu vizinho é Ernesto Gonzales, um imigrante mexicano, casado e pai de quatro filhos, que sente orgulho de viver na América, onde trabalha como operário. Aos poucos, as duas famílias vão se conhecendo.
Zach Villa • Judah Friedlander • Hank Azaria • Missi Pyle • Jacqueline Pinol • Efren Ramirez • Alex Borstein • Nicholas Gonzalez
Bud is enraged when he finds out that his daughter Becky is engaged to J.C., Ernesto’s nephew who just graduated from college. Meanwhile, a staunch anti-immigration law is passed which eventually leads to J.C.’s deportation, much to Bud’s delight.
Bud fights to get a border wall constructed using confiscated drug money, only to have the wall destroy the economy, leaving him jobless. He then begins smuggling immigrants under the wall to make ends meet .
The reverend of Bud’s megachurch asks Bud to lure Ernesto, the town’s biggest church donor, away from the local Mexican Catholic church, to help fill their coffers. Ernesto is seduced by the glitziness of the church, and the reverend schemes to bring over all the other Mexican residents by “Hispandering,” to Bud’s horror. Bud and Ernesto team up to restore the status quo, but their plan backfires.
Bud becomes the high school football coach after the previous coach is forced out of the job by the local redneck fans.
The Mexifornia population tips from white majority to Latino majority when Maria's sister has a baby, so Bud wants Janice to have another baby in order to even the shift.
Frustrated that J.C. still hasn't gotten a job, Ernesto hires him as part of his landscaping crew. When the job turns out too difficult, J.C. unionizes Ernesto's workers and begins a strike.
Bud unwittingly becomes drug kingpin Pablo Barracuda’s inside man at the Border Station, as he competes to be richer and more successful than Ernesto.
Bud helps a Mexican “Bud” look-alike sneak over the border, so he can take a break from his own life.
Gert’s unhealthy eating causes her to have a heart attack during the Little Miss Mexifornia Pageant. Unable to afford the surgery in America, Bud takes her to Mexico to have her arteries unblocked and heart repaired. Meanwhile, Ernesto and Maria put Pepito on medication that makes him behave, but they don’t like the side effects.
Residents are ordered to leave Mexifornia when it is threatened by wildfire, but Bud stays put and his house catches fire, requiring Ernesto to rescue him. Meanwhile J.C. and Becky take a relationship break and agree to see other people.
Ernesto and Placido are thrilled that their favorite TV show, “La Fiesta Noche,” will be filming in Mexifornia. The Buckwalds and Gonzalezes both get tickets to the taping, but Bud’s anger at the spectacle causes him to be called onto the stage. Much to everyone’s surprise, the audience loves him and he becomes a big star in the Mexican community in the all-new “La Fiesta Noche Show”
